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Although the pattern of adverse reactions in this study seems somewhat different from that seen in patients with partial seizuresthis is likely due to the much smaller number of patients in this study compared to partial seizure studiesThe adverse reaction pattern for patients with primary generalized tonic-clonicPGTCseizures is expected to be essentially the same as for patients with partial seizures.

Patients should be monitored for these signs and symptoms and advised not to drive or operate machinery until they have gained sufficient experience on KEPPRA to gauge whether it could adversely affect their ability to drive or operate machinery.

Table 9Adverse Reactions in a Placebo-ControlledAdd-On Study in Patients cheap tadalis. 4 Years of Age and Older with PGTC Seizures.

Antiepileptic drugsincluding KEPPRAshould be withdrawn gradually to minimize the potential of increased seizure frequency.

In the controlled clinical study that included patients 4 years of age and older with PGTC seizuresthe most common adverse reaction in patients receiving KEPPRA in combination with other AEDsfor events with rates greater than placebowas nasopharyngitis.

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