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Bray et al 29 , in 2006, measured the cellular accumulation ratio car of chloroquine in six experimental conditions, namely in sensitive and resistant strains, in the absence and presence of carbonylcyanide p-trifluoromethoxyphenylhydrazone fccp , a ionophoric uncoupling agent, and in the absence and presence of glucose.

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Convulsionsif presentshould be controlled before attempting gastric lavageIf due to cerebral stimulationcautious administration of an ultra short-acting barbiturate may be tried butif due to anoxiait should be corrected by oxygen administration and artificial respirationMonitor ECGIn shock with hypotensiona potent vasopressor should be administeredReplace fluids and electrolytes as neededCardiac compressing or pacing may be indicated to sustain the circulationBecause of the importance of supporting respirationtracheal intubation or tracheostomyfollowed by gastric lavagemay also be necessaryPeritoneal dialysis discount toradol medication. and exchange transfusions have also been suggested to reduce the level of the drug in the blood.

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In vitro studies with trophozoites of Entamoeba histolytica have demonstrated that chloroquine also possesses amebicidal activity comparable to that of emetine.

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