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Other drugs metabolised by cyp2d6 fluoxetine is a strong inhibitor of cyp2d6 enzyme, therefore concomitant therapy with drugs also metabolised by this enzyme system may lead to drug interactions, notably those having a narrow therapeutic index such as flecainide, propafenone and nebivolol and those that are titrated, but also with atomoxetine, carbamazepine, tricyclic antidepressants and risperidone.